Tag: methacholine

Chronic Cough Due to Asthma: Treatment

Despite the demonstrated efficacy of therapy with LTRAs in patients with CVA, the question of whether these agents are sufficient as monotherapy, or whether they should be used in addition to inhaled steroids, remains unresolved at this time, Subepithelial layer thickening, a pathologic feature of airway wall remodeling, is present in CVA, although to a […]

Chronic Cough Due to Asthma: Recommendation

Patients with cough due to asthma should initially be treated with a standard antiasthmatic regimen of inhaled bronchodilators and inhaled corticosteroids. Quality of evidence, fair; net benefit, substantial; grade of recommendation. A potential pitfall of inhaled steroid therapy in patients with CVA is that the treatment itself may induce or exacerbate cough, which is likely […]

Chronic Cough Due to Asthma: Evaluation

If reversible airflow obstruction is demonstrated in a patient with chronic cough, empiric therapy for asthma is appropriate, However, a patient with chronic cough due to asthma may present a diagnostic challenge, because physical examination and pulmonary function test results can be entirely normal, In this setting, bronchoprovocation testing with inhaled methacholine should be used […]

Chronic Cough Due to Asthma

Multiple prospective studies have shown that asthma is among the most common etiologies of chronic cough (24 to 29%) in adult nonsmokers, Usually, cough is associated with the more typical symptoms of dyspnea and wheezing, Alternatively, an isolated cough may serve as a harbinger of future asthmatic episodes, In a subgroup of asthmatic patients, however, […]

Normal Range of Methacholine Responsiveness in Relation to Prechallenge Pulmonary Function: Comment

The failure of FEVj-specific normal ranges of PD20FEVJ to improve sensitivity or specificity in detecting questionnaire-reported asthma or wheezing has several possible explanations. Measurements of airway responsiveness are imperfect at discriminating between asthmatics and nonasthmatics in population samples,’ and altering the criteria for an abnormal challenge test may have little impact relative to other sources […]

Normal Range of Methacholine Responsiveness in Relation to Prechallenge Pulmonary Function: Conclusion

A number of mechanisms have been proposed as the basis for the relationship between nonspecific airway responsiveness and prechallenge pulmonary function.’ Because resistance to flow through a tube is inversely proportional to the radius to the fourth power, a given degree of bronchoconstrictor-induced circumferential airway narrowing can be expected to cause a proportionally larger increase […]