Between April 1984 and June 1990, 1,410 men reported for at least one examination. Two hundred fifteen subjects were lifetime nonsmokers and denied any history of respiratory illness or symptoms. Regression analysis restricted to these 215 subjects yielded the following equations: Predicted FVC (L) = -4.46 + 0.155 height (in) – 0.0324 age (yrs) Predicted […]
Methacholine inhalation challenge testing was performed as previously described. Solutions were aerosolized by a nebulizer (DeVilbiss 646) powered by an air compressor (DeVilbiss). All inhalations were 6-s vital capacity inhalations followed by 2 s of breathholding. Seconds were counted aloud from a digital stopwatch after careful instruction and practice. Inhalations were done seated and wearing […]
Sample The Normative Aging Study is a longitudinal cohort study of health and aging established at the Veterans Administration’s Outpatient Clinic in Boston in 1963. Volunteers were recruited by advertisement and accepted into the study only if initial health screening revealed no evidence of chronic diseases including asthma, sinusitis, hypertension, or heart disease. The initial […]
Methacholine challenge testing is currently being used as a diagnostic test for a variety of clinical indications. In patients presenting with chronic cough of uncertain cause, challenge testing has been advocated as a means to determine whether the cough is associated with airway hyperresponsiveness (“cough variant asthma”) and likely to respond to bronchodilator therapy. Methacholine […]