In our study, as in previous data, the vasoconstrictor effects of ANGII were accompanied by a baroreflex fall in SV and CO, which occurred even at the lowest dose of 2 ng/kg/min. It is interesting to note in this respect that even in patients with decompensated edematous CP, an increase in CO occurs in the […]
The results of the present study showed that ANGII produced dose-related pressor effects on both the pulmonary and systemic vascular bed. However, the pulmonary vasculature was proportionately more sensitive to the vasoconstrictor effect of ANGII in comparison with the systemic vasculature. The increase in MPAP in response to the 4 ng/ kg/min dose of ANGII […]
There were dose-related increases in concentrations of plasma ANGII (pmol/L), with significant differences between baseline and the three dose levels: baseline 32.9 (16.6 to 49.1); 2 ng/kg/min, 71.0 (54.8 to 87.3); 4 ng/kg/min, 112.3 (96.1 to 128.5); and 6 ng/kg/min, 148.4 (132.2 to 164.7). Numerical data for all other responses are shown in Table 1 […]
All hemodynamic parameters were recorded during the last 10 min of each 30-min infusion period. Heart rate (HR) was recorded from an ECG monitor, with an average stable rate being taken over a 1-min period. Blood pressure was measured using a semiautomated sphygmomanometer (Dinamap vital signs monitor, Critikon, Tampa, Fla) with the mean of five […]
Activation of the renin-angiotensin system occurs in patients with hypoxemic cor pulmonale, with raised circulating levels of angiotensin II (ANGII) and aldosterone (ALDO).” The elevated levels of ALDO are responsible for producing renal-medi-ated sodium and water retention that manifests as edema in patients with cor pulmonale. The systemic pressor effects of ANGII are well documented, […]