News (Page 5)

Tracheobronchial Amyloidosis: Conclusion

Kurrus et al reported one of the first intentional uses of external beam radiation therapy for TBA. The patient was initially observed until the development of life-threatening, progressive obstruction. External beam radiation therapy was then delivered to the distal trachea and right mainstem bronchus using a dose of 20 Gy in 10 fractions with improvement. […]

Tracheobronchial Amyloidosis: Pulmonary

Management has primarily consisted of debulking procedures and laser ablation. Unfortunately, such methods may be ineffective and repeated procedures may be required. Capizzi et al reported 17 patients with TBA who were treated with laser or forceps resection, systemic therapy, radiation, or observation. Of 13 patients with follow-up data, 6 patients were alive with recurrence, […]


Tracheobronchial Amyloidosis: Discussion

In October 2001 and July 2002, CT scans of the chest demonstrated progressive resolution of thickening in the right mainstem bronchus and marked improvement in right lower lobe airspace disease/atelectasis. The most recent CT scan of the chest obtained in November 2002 revealed a continued improvement in the thickening of the right mainstem bronchus and […]


Tracheobronchial Amyloidosis: Abnormally thickened mucosa

The patient was thought not to be a candidate for laser resection or stent placement given the diffuse involvement of the airways and the extent of the disease into the distal airways. Due to the lack of therapeutic options, it was elected to provide a trial of external beam radiotherapy. Beginning in July 2001, the […]


Tracheobronchial Amyloidosis: CT

A CT scan of the chest demonstrated a central lung mass at the level of the right mainstem bronchus. Flexible bronchoscopy revealed thickening of the distal trachea and obstruction of the right mainstem bronchus by a tumor-like exophytic mass. Pathology from endobronchial biopsies revealed bronchial mucosa with squamous metaplasia. Rigid bronchoscopy was performed and demonstrated […]

Tracheobronchial Amyloidosis

Amyloidosis is a disorder of extracellular protein deposition that encompasses a wide spectrum of related diseases. The underlying pathology involves abnormal protein folding and results in insoluble amyloid fibril proteins accumulating in normal tissues. Various subtypes exist, including primary systemic amyloidosis, reactive systemic amyloidosis associated with chronic inflammatory states, and localized forms of aberrant amyloid […]

Continuous Noninvasive Measurement of Pulsus Paradoxus Complements Medical Decision Making in Assessment of Acute Asthma Severity: Limitations

In reality, the complexities of optical plethysmography, along with their inherent noise, may preclude the utility of a simple relationship in a pulse oximeter that also displays PP. Filtering and straightforward signal-processing methods like least mean squares approximation and best uniform approximation will be needed to take this next step. Expert systems have appeared in […]