A computer model originally developed by Persons et al was modified according to MMAD and GSD and used to calculate regional deposition of the 18 aerosols. The human lung model was based on the following parameters: mouth breathing, functional residual volume 3,300 ml, tidal volume 750 ml, inspiration 2 s, expiration 2 s, no pause. […]
The Вес-DLPC liposomes in water (initial Bee concentration 0.5 mg/ml) were added to the jet nebulizer reservoir according to the maximum volume (Table 1). The nebulizers were selected at random and operated using dry compressed air at flow rates prescribed by the manufacturer’s instructions or at 7.5 to 8 L/min (Table 1). buy claritin online […]
Localized aerosol delivery of drugs to the respiratory tract is becoming an increasingly important and effective therapeutic method for treating a variety of pulmonary disorders. In this regard, several different devices have been used, including continuous-flow, jet nebulizers. To date, jet nebulizers have been used predominantly to administer aqueous preparations of soluble drugs such as […]
The good results in published series have not been without associated morbidity and, at times, mortality. A discussion of complications for a procedure which, in many patients, is largely of palliative intent is essential. In general, the complication rates have varied, with the most common complications being radiation-induced bronchitis, fistulae, and pulmonary hemorrhage. All patients […]
The most common symptoms caused principally by an endobronchial component due to bronchogenic carcinoma include hemoptysis, shortness of breath, cough, and postobstructive pneumonia. Endobronchial irradiation is a relatively simple procedure enabling delivery of an effective tumoral dose to a small volume without exceeding normal tissue tolerance. The value of endobronchial irradiation is especially evident in […]
Of the 32 patients studied, 16 were alive at the time of this evaluation. Two of these patients were subsequently diagnosed and treated for metastasis to the brain, and one was diagnosed and treated for a spinal cord compression. The median follow-up after brachytherapy was 9.3 months, with a range from 6 to 24 months. […]
Between June 1990 and April 1992, there were 32 patients who underwent 80 high dose-rate endobronchial applications. The median age was 59 years, with a range from 49 to 80 years. Thirty had primary malignant neoplasms of the lungs, and two had nonpulmonary tumors, one primary cervical carcinoma and one primary carcinoma of the colon […]