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Cognizant of the preclinical data, substantial efforts were made to investigate the visual effects of sildenafil during clinical development. A number of Phase II and III studies were carried out to determine the safety of sildenafil in relation to the retina and visual function. Much of the data, with complete study descriptions, will appear in print shortly. Initially, short-term studies were performed to investigate the acute effects of sildenafil on the eye. These were followed by much longer studies to determine the consequences of chronic exposure of sildenafil (Viagra) on retinal function.
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