Animal studies performed over four decades ago showed that vasopressin (Pitressin) produced a marked reduction in coronary blood flow. Based on these data, its administration was proposed as a test of “coronary insufficiency.” In 1947, Rusldn reported that when vasopressin was given to individuals with typical angina pectoris, electrocardiographic changes developed that were comparable to those induced by exercise testing. Furthermore, the author urged caution with its use in this setting: “otherwise serious and even fatal myocardial ischemia and necrosis may result.” Nevertheless, intramuscular injections of vasopressin were in common use at that time to eliminate intestinal gas prior to cholecystography. Several instances of acute […]