Category: Asthma (Page 3)

Efficacy of a Heat Exchanger Mask in Cold Exercise-Induced Asthma: Summary

It may be a promising adjunctive therapy for asthmatics that want to work, exercise, or spend time in the cold, particularly for those individuals who still experience symptoms of EIA after pretreatment with albuterol. One potential explanation for improved exercise lung function with the device is the expiratory resistance afforded by the system. If back […]

Efficacy of a Heat Exchanger Mask in Cold Exercise-Induced Asthma: Conclusion

In fact, the efficacy of this mask may have been underestimated in both studies with the inclusion of data from the subjects needing early albuterol rescue after placebo exercise. Their maximal decline in FEV1 may have been much greater in that visit, had we not prevented further decline in lung function with albuterol administration. While […]

Efficacy of a Heat Exchanger Mask in Cold Exercise-Induced Asthma: Discussion

The treatment of patients with predominantly EIA symptoms usually involves pretreatment with an inhaled short-acting bronchodilator. This approach is highly effective and is associated with minimal cost and adverse effects, so the benefit of any new device or treatment for EIA should be at least as effective as albuterol pretreatment. We intended to address this […]

Efficacy of a Heat Exchanger Mask in Cold Exercise-Induced Asthma: Results

Because some subjects met criteria for EIA with placebo exercise (“responders”) and some did not (“nonresponders”), we analyzed the data separately to see if the mask improved lung function in the seven nonresponders. For responders, the mean declines in FEV1 during placebo and active device exercise were 34% and 8%, respectively (p = 0.02). For […]

Efficacy of a Heat Exchanger Mask in Cold Exercise-Induced Asthma: Methods

Spirometry was performed at 5, 15, and 30 min after exercise, and subjects were rescued with albuterol if they demonstrated a > 40% decline in FEV1 at any time. The primary outcome for both studies was the maximum postexercise percentage decline in FEV1. Secondary outcomes included the percentage decline in maximum mid-expiratory flow (FEF25-75), FEF25-75/FVC […]

Efficacy of a Heat Exchanger Mask in Cold Exercise-Induced Asthma: Materials

Exclusion criteria included the presence of other lung diseases, use of systemic or inhaled glucocorticoids within 6 weeks, use of leukotriene inhibitors within 4 weeks, and symptoms of upper or lower respiratory tract infection within 6 weeks. Study 1 subjects participated in three visits. At visit one, spirometry and methacholine challenge were performed. Visits two […]

Efficacy of a Heat Exchanger Mask in Cold Exercise-Induced Asthma

Exercise-induced asthma (EIA) is present in up to 90% of all patients with asthma, and exercise is one of the most common precipitants of acute asthma. While pre-exercise inhalation therapy aimed at reducing EIA may help significantly, many patients are left with limitations in their ability to exercise, particularly in cold weather, and some patients […]