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Continuous Noninvasive Measurement of Pulsus Paradoxus Complements Medical Decision Making in Assessment of Acute Asthma Severity: Relationship Between Objective Scoring and PP

All variable distributions were assessed for violation of the assumption of normality based on skewness, the Shapiro-Wilk statistic (a = 0.01), and visualization. Variables having a significant deviation from normal via the Shapiro-Wilk statistic were submitted to the following three linear transformations: square root; natural logarithm; and inverse. The linear transformation that improved the distribution […]

Continuous Noninvasive Measurement of Pulsus Paradoxus Complements Medical Decision Making in Assessment of Acute Asthma Severity: Measurement of AT-PP

Continuous BP measurements were obtained noninvasively with a wrist mounted arterial tonometer (NCAT; Nellcor; Pleasanton, CA). The analog output of this device was digitized via an eight-bit analog-to-digital converter (DAQ-500; National Instruments; Austin, TX) [Fig 1]. The sampling rate was 200 Hz. A peak-seeking periodic amplitude analysis algorithm was designed (LabVIEW; National Instruments) that would […]

Continuous Noninvasive Measurement of Pulsus Paradoxus Complements Medical Decision Making in Assessment of Acute Asthma Severity: Prospective Cohort

Patients and Protocol: Adult patients who were 18 to 70 years of age, had a documented history of asthma, and were presenting with shortness of breath and probable asthma exacerbation were approached for study enrollment by trained clinical research assistants. Informed consent was obtained during the ED triage process or shortly thereafter, before ED treatment […]