Monthly Archives: April 2014

Relationship Between Expired Capnogram and Respiratory System Resistance in Critically III Patients During Total Ventilatory Support – Methods

Modern ventilator monitoring includes the measurement of airway pressures and derived intermittent calculations such as respiratory system resistance (Rrs). Patients in the ICU receiving mechanical ventilation often exhibit high Rrs due to bronchospasm, structural airway abnormalities, low lung volume, and retained bronchial secretions both attached to the airways or to the wall of the endotracheal […]

N-Acetylcysteine Enhances Recovery From Acute Lung Injury in Man – Discussion

Despite major improvements in patient care, ARDS still remains a formidable clinical challenge and carries a high mortality rate. Recent clinical studies suggest that patients with ARDS undergo relevant oxidative stress. Toxic oxygen products cause cellular and subcellular damage and activate epithelial cells, macrophages, or endothelial cells. Oxygen radicals are also recognized as mediators between […]

N-Acetylcysteine Enhances Recovery From Acute Lung Injury in Man – Results

Statistical Methods Initial homogeneity assessment of the two groups was performed by t test and x2 analysis. The before and after comparisons were done with the sign test, the paired t test, and the Wilcoxon-Pratt test depending on the distribution of the data. Between-group comparisons were performed with the X2 test, the Student t test, […]

N-Acetylcysteine Enhances Recovery From Acute Lung Injury in Man – Methods

Multiple trauma included patients with multiple major fractures (two or more major long bones or unstable pelvic fracture) associated with trauma to another region of the body such as craniocerebral or abdominal, requiring surgical intervention. Aspiration was defined as recent (during the previous 6 h) inhalation of gastric contents, documented by suctioning of gastric material […]

N-Acetylcysteine Enhances Recovery From Acute Lung Injury in Man – Subjects and Protocol

Acute lung injury characterized by a high-permeability, low-pressure pulmonary edema can develop following a number of predisposing diseases resulting in different degrees of respiratory insufficiency. Patients with mild-to-moderate injury could, within this continuum, represent an interesting subset to evaluate a therapeutic approach of lung dysfunction. The pathogenesis of acute lung injury and its severest form, […]

Operating Characteristics of 18 Different Continuous-Fiow Jet Nebulizers With Beclomethasone Dipropionate Liposome Aerosol – Discussion

Jet nebulizers have typically been used to dispense water-soluble drugs from water or saline solution media. Many of the physical factors that control these aerosols have been studied, including the effect of air flow and pressure, changes in hygroscopicity resulting from dissolved salt or drugs, as well as design characteristics of the nebulizers. The ultimate […]