Because the term acid reflux disease when applied to chronic cough due to GERD can be a misnomer and may mislead clinicians into thinking that all patients with cough due to GERD should improve with acid-suppression therapy, it is recommended that the term acid reflux disease no longer be used in the context of cough unless it can be definitively shown to apply. Unless acid reflux disease can be definitively proven, the more general term reflux disease should be used.
Because coughing can induce GER episodes, a cough-GER self-perpetuating cycle may be involved in the pathophysiology of a patient’s chronic cough. While cough-induced GER episodes are often observed in 24-h esophageal pH-monitoring tracings, the mechanisms by which these GER episodes are triggered by coughing is not known. www.mycanadianpharmacy.com
Based on inhaled tussigenic cough challenges, there is little evidence to support the theory that an increased sensitivity of the cough reflex is the sole explanation why some patients with GERD complain only or predominantly of cough, while others primarily have GI complaints. An increased sensitivity has been observed in patients with GERD who do not cough as well as in those who do cough.
…click here to read more